Femme — Women's Wellness Serum (1 fl oz / 30mL)

Femme is a topical progesterone serum designed for women's hormonal balance and well-being. Its formula blends natural progesterone with a coconut oil base for optimal transdermal absorption, delivering precise progesterone support without the systemic side effects of oral hormone therapy.

• Natural Progesterone — 20mg per 1mL dose
• Base: Coconut oil for optimal transdermal absorption and skin moisturization
• Supports hormonal balance and well-being
• Eases PMS symptoms and supports cycle regularity
• Promotes better sleep and reduces hormonal anxiety
• Moisturizes and nourishes skin while aiding absorption
• Made with natural ingredients — clean and pure formula

Size: 1 fl oz (30mL) | Dose: 1mL per application | Brand: Glow Essentials by Physician Designed

VARS Liposomal Glutathione — Master Antioxidant & Liver Detox (60 Capsules)

Glutathione is the liver’s primary detoxification molecule, essential for phase II conjugation of hormonal metabolites including estrogen. It also reduces oxidative skin damage, supports immune function, and protects cellular structures from oxidative stress.

• VARS Liposomal Glutathione — 275mg per serving (active reduced GSH, stable 1+ year)
• Other Ingredients: Vegetable capsule, gum arabic, sunflower lecithin, sodium alginate, rice bran
• of: GMOs, Gluten, Nuts, Dairy, Fish, Shellfish, Soy

Serving Size: 2 Capsules | Servings: 30 | 60 Capsules Total

MTHFR Daily — Methylation Multivitamin (120 Capsules)

MTHFR Daily provides vitamins and minerals in their active, bioavailable forms — bypassing the MTHFR enzyme entirely. Methylation is the upstream prerequisite for proper hormonal metabolism, neurotransmitter synthesis, and liver detox capacity.

• Methylfolate (800mcg DFE as folinic acid calcium salt) — required for estrogen methylation and
• Vitamin B12 (800mcg as adenosylcobalamin and hydroxocobalamin) — 33,333% DV
• Vitamin B6 (10mg as pyridoxal-5-phosphate) — cofactor in hormone metabolism and neurotransmitter synthesis, 588% DV
• Riboflavin B2 (50mg as riboflavin-5-phosphate) — essential MTHFR cofactor, 3846% DV
• Magnesium Glycinate (100mg), N-Acetyl L-Cysteine (100mg), Zinc (2mg), Selenium (75mcg)
• Full B-complex plus Alpha Lipoic Acid, Myo-Inositol, Choline

Serving Size: 4 Capsules | Servings: 30 | 120 Capsules Total

• Restores Hormonal Balance — Femme delivers precise topical progesterone to counterbalance estrogen dominance. MTHFR Daily restores the methylation capacity needed for the liver to properly conjugate and clear estrogen metabolites. Together they address hormonal imbalance from both the supply and sides.
• Supports Liver Detox of Hormonal Metabolites — Methylation (via MTHFR Daily) and glutathione (via VARS) are both essential for liver phase II detoxification of estrogen and progesterone metabolites. Impaired methylation or low glutathione allows harmful hormonal metabolites to recirculate, worsening hormonal symptoms.
• Eases PMS & Menstrual Discomfort — Progesterone deficiency is a primary driver of PMS symptoms. Femme provides direct progesterone support. B6 (as P5P) in MTHFR Daily is a cofactor in serotonin synthesis, supporting mood stability throughout the cycle.
• Perimenopause & Menopause Support — As progesterone declines with age, the estrogen-to-progesterone ratio shifts, driving perimenopausal symptoms. Femme provides topical progesterone support. Methylation and glutathione support the liver’s ability to process the changing hormonal landscape.
• Skin Health & Brightening — Glutathione inhibits melanin synthesis and reduces oxidative skin damage. Progesterone supports skin hydration and elasticity. Methylation supports healthy cell renewal and collagen synthesis. This stack provides comprehensive skin support from the inside and outside.
• Promotes Better Sleep & Reduces Hormonal Anxiety — Progesterone has natural calming, GABA-modulating effects that promote sleep and reduce anxiety. Magnesium glycinate in MTHFR Daily further supports GABA and stress resilience. Glutathione reduces the oxidative burden that disrupts sleep quality.
• Mood Stability — Methylation drives serotonin and dopamine synthesis. Progesterone modulates GABA receptors. Together they provide comprehensive mood support addressing both neurotransmitter production and hormonal mood regulation.
• Anti-Aging — Glutathione protects cellular structures from oxidative damage. Methylation regulates gene expression and DNA repair. Progesterone supports skin elasticity and hydration. Together they address cellular aging from multiple angles.

• Femme Serum: Apply 1mL (1 full dropper) topically to thin-skinned areas (inner wrist, inner arm, neck, chest) once daily. Rotate application sites. applied in the evening to support sleep and overnight hormonal restoration.
• VARS Liposomal Glutathione: Take 2 capsules daily, with or without food
• MTHFR Daily: Take 4 capsules daily with food
• to take capsules in the morning and apply Femme in the evening for optimal daily hormonal support
• Store Femme serum in a cool, dry place. Store capsules away from direct sunlight and heat
• Keep out of reach of children

Why They Work Better Together:

• Methylation (MTHFR Daily) is required for the liver to methylate and clear estrogen metabolites — without it, even supplemental progesterone cannot fully correct the estrogen-to-progesterone ratio
• Glutathione supports the liver’s phase II detox of hormonal metabolites, extending the effectiveness of both Femme and MTHFR Daily’s hormonal support
• NAC in MTHFR Daily supports glutathione recycling, amplifying VARS Glutathione’s liver detox capacity
• Consistent daily use of all three is essential — hormonal rebalancing and methylation optimization are cumulative processes

Stack Further:

• Add — SOD and Vitamin C complete the antioxidant cycle and amplify skin and cellular protection
• Add — Brite Brain adds cognitive and mood support alongside the hormonal balance benefits of this stack

Q: Why does methylation matter for hormonal balance?A: The liver uses methylation to conjugate and clear estrogen metabolites through a process called estrogen methylation. When methylation is impaired — as it is in those with MTHFR gene variants — estrogen metabolites are not properly cleared, leading to estrogen dominance, worsened PMS, mood swings, and hormonal skin issues. MTHFR Daily restores methylation capacity using active, pre-converted B vitamins that bypass the MTHFR enzyme, enabling the liver to properly process and clear hormonal metabolites.

Q: How does topical progesterone work differently from oral progesterone?A: Topical progesterone bypasses first-pass liver metabolism, delivering progesterone directly through the skin into the bloodstream. This allows for more precise dosing and avoids the conversion of oral progesterone to metabolites that can cause drowsiness and other side effects. Femme uses a coconut oil base specifically chosen for optimal transdermal absorption.

Q: Is this bundle suitable for perimenopause?A: Yes — the Hormonal Balance & Skin Stack is well-suited for perimenopause, when declining progesterone levels shift the estrogen-to-progesterone ratio and drive symptoms like hot flashes, mood changes, sleep disruption, and skin changes. Femme provides direct progesterone support; MTHFR Daily and VARS Glutathione support the liver’s ability to process the changing hormonal environment. consult your healthcare provider before starting hormonal supplementation.

Q: What’s included in this bundle?A: One bottle of Femme Women's Wellness Serum (1 fl oz / 30mL), one bottle of VARS Liposomal Glutathione (60 capsules, 30-day supply), and one bottle of MTHFR Daily (120 capsules, 30-day supply).

Q: How long before I notice results?A: Many women notice improvements in sleep, mood, and PMS symptoms within 2–4 weeks of consistent use. Skin benefits and deeper hormonal rebalancing typically build over 2–3 months of continued use.

Q: When will my order ship?A: Orders ship Monday through Friday with a 3 business day processing time. You will receive an email notification when your order ships.

Allergen Information: VARS Liposomal Glutathione is of GMOs, gluten, nuts, dairy, fish, shellfish, and soy. Femme contains coconut oil. If you have any food allergies, sensitivities, are pregnant, nursing, or taking medications or hormone therapy, please consult your healthcare provider before use. Keep out of reach of children.